What is the difference between Windows 10 Enterprise E3 and E5?

Both Windows 10 Enterprise E3 and E5 come with features such as Credential guard, Device guard, Applocker Management, Microsoft Application Virtualization (App-V) and Managed User experience. On top of that Windows 10 E5 also comes with Windows Defender Advanced Threat Protection (ATP). Windows Defender ATP detects attacks and zero days using advanced behavioral analytics and Machine Learning to uncover breach of network in an organization. With Windows 10 ATP, the customer can quickly respond to contain the cybersecurity attack and prevent reoccurrence of a future security breach. More details about Windows 10 ATP can be found here.